The two biggest changes from the manga that I saw were that Clare didn’t have to awaken nearly as much in order to defeat Ligardes (though they did make it clear that she was pushing herself harder and harder), and that Raki was put on the scene. Raki, however, didn’t really do anything except be shocked and be frustrated, though he may yet play a part in turning Clare back - assuming that’s the direction the story is gonna go.

Then again, Jean’s still alive, and Galatea is in the preview, so any one of them (or even all of them) could play that part, and it’s possible that Clare’s physical changes will also manifest themselves in the next episode.

Priscilla and Isley still have a part to play too, so maybe Clare will get to fight one of them (maybe both) while she’s still uber-powerful. Regardless, it should be pretty much all anime-original material from here on out.